Retinoic acids up-regulate functional eosinophil-driving receptor CCR3.
Allergy
; 68(7): 953-6, 2013 Jul.
Article
in En
| MEDLINE
| ID: mdl-23742077
ABSTRACT
Eotaxins and their receptor CCR3 have a definitive role for tissue accumulation of eosinophils both under homeostatic and pathologic conditions. However, physiological stimuli that can up-regulate CCR3 in blood-derived human eosinophils have not been recognized. As a prior gene microarray study revealed up-regulation of CCR3 in eosinophils stimulated with retinoic acids (RAs), the expression of functional CCR3 was examined. We found that 9-cis RA and all-trans RA (ATRA) significantly induced surface CCR3 expression regardless of the presence of IL-3 or IL-5. Pharmacological manipulations with receptor-specific agonists and antagonists indicated that retinoic acid receptor-α activation is critical for CCR3 up-regulation. RA-induced CCR3 was associated with its functional capacity, in terms of the calcium mobilization and chemotactic response to eotaxin-1 (CCL11). Our study suggests an important role of vitamin A derivatives in the tissue accumulation of eosinophils.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tretinoin
/
Chemotaxis, Leukocyte
/
Dermatitis, Atopic
/
Eosinophils
/
Receptors, CCR3
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Allergy
Year:
2013
Document type:
Article
Affiliation country: